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Sildenafil metabolism is principally mediated by CYP3A4 (major route) and CYP2C9 (minor route). Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. The concomitant use of erythromycin or strong CYP3A4 inhibitors (e.g., saquinavir, ketoconazole, itraconazole) as well as the nonspecific CYP inhibitor, cimetidine, is associated with increased plasma levels of sildenafil [see Dosage and Administration (2.4)].How does Viagra treat male impotence?

Efficacy Results from Controlled Clinical Studies1.Uninsured or Underinsured levitra on line Stress - for example, due to a difficult work or home situation.Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Brand name prescription drugs are protected under patent. When the patent expires, other drug companies can start manufacturing and selling a generic form of the drug that is usually less expensive. The patent for Viagra (sildenafil) will not expire until 2012; therefore, no generic, less expensive form is currently available. Consult your physician or healthcare provider for specific recommendations on potential alternatives to Viagra treatment. Sarah Lewis, PharmD Renal impairment (such as Adcirca [tadalafil])

kidney or liver problemsOtologic — Cases of sudden decrease or loss of hearing have been reported postmarketing in temporal association with the use of PDE5 inhibitors, including Cialis. In some of the cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events. In many cases, medical follow-up information was limited. It is not possible to determine whether these reported events are related directly to the use of Cialis, to the patient's underlying risk factors for hearing loss, a combination of these factors, or to other factors [see Warnings and Precautions (5.5)]. viagra pills

Medicines are sometimes prescribed for conditions other than those described in patient information leaflets. Do not use Levitra for a condition for which it was not prescribed. Do not give Levitra to other people, even if they have the same symptoms that you have. It may harm them.

have blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia 10 mg cialis The role of transporters (for example, p-glycoprotein) in the disposition of tadalafil is not known. Therefore, there is the potential of drug interactions mediated by inhibition of transporters.When taking CIALIS with large amounts of alcohol, some men may experience dizziness.

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